When Screen Reader is enabled, swipe up on the touchpad to request a narrated description of your current status.
When the player character is in a crouched position they may not be able to interact with doors or other things that are needed to progress. Check your status and attempt to progress from standing or crouching.
If you are receiving a disabled navigation sound, scan for enemies as you may need to eliminate all enemies before being able to progress. Navigation assistance will then return.