How do I enable Lock-On Targeting?

Lock-On Targeting can be manually enabled by following this menu pathway:

Options > Accessibility > Alternate Controls > Lock-On Aim [Off/On/Auto-Target]

• Additional option available for tuning Lock-On Strength

When set to On, Lock-On Aim will target enemies who are onscreen. To lock-on to offscreen enemies as well, select Lock-On Aim > Auto-Target. 

Note: Lock-On Targeting is included in the Vision Accessibility Preset and the Motor Accessibility Preset.

Lock-On for throwable weapons is Arc-Throw Lock-On. It must be enabled separately from Lock-On Aim. It causes bricks/bottles to lock on slightly away from the target when in stealth to facilitate distractions. Toggle Arc-Throw Lock-On by following this menu pathway:

Options > Accessibility > Alternate Controls > Arc-Throw Lock-On [Off/On]